TY - JOUR TI - Mathematical model for studying genetic variation in terms of restriction endonucleases. AU - M Nei AU - Wen‐Hsiung Li PY - 1979 JO - Proceedings of the National Academy of Sciences DO - 10.1073/pnas.76.10.5269 UR - https://doi.org/10.1073/pnas.76.10.5269 AB - A mathematical model for the evolutionary change of restriction sites in mitochondrial DNA is developed. Formulas based on this model are presented for estimating the number of nucleotide substitutions between two populations or species. To express the degree of polymorphism in a population at the nucleotide level, a measure called "nucleotide diversity" is proposed. ER -