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2022 · EAST AFRICAN JOURNAL OF MANAGEMENT AND BUSINESS S…

Development and Validation of Questionnaire for Physics Learning Self-Efficacy among Ghanaian Senior High Schools

Eric Appiah-Twumasi, Yaw Ameyaw, Ishmeal Kwasi Anderson

This study focused on developing an instrument for assessing Senior High School students Physics learning self-efficacy beliefs. An instrument known as PLSE was administered on-site and in-person. The PLSE was tested on 290 final year Senior High School Physics students. Prior to this, the initial scale was administered to 60 Senior High School Physics students after validation by seven experts of Science educators. The PCA extracted four factors with loadings ranging from 0.588 to 0.889. The four factors were Physics Practical, Every Application of concepts, High-Order Thinking Skills and Physics Content. The calculated Average Variance Extracted (AVE), and Composite Reliability of the PLSE items were also found to range from 0.540 to 0.718 and 0.823 to 0.927 respectively. The subsequent reliability results showed excellent internal reliability for each of the sub-scales with Corrected Item-total Correlation (CIC) values, ranging between 0.571 and 0.752. Validity, and reliability assessments revealed accepted threshold cut-off of Average Variance Extracted (AVE), Composite Reliability (CR,) and Cronbach's Alpha coefficient. This paper suggests that the current proposed Physics learning instrument represent a reliable research scale to measure Senior High students Physics learning self-efficacy belief.

3 citations2 viewsFull text
DOI: 10.46606/eajess2022v03i01.0141
2022 · IOP Conference Series Materials Science and Engin…

IOP Conference Series: Materials Science and Engineering

International Nuclear Science, Technology and Engineering Conference 2021 (iNuSTEC2021) “Nuclear Science and Technology for Socio-economic Development” Universiti Teknologi Malaysia (UTM) Skudai, Johor, Malaysia 10-12 October 2021 Editors Nahrul Khair Alang Md Rashid, Universiti Teknologi Malaysia Khaidzir Hamzah, Universiti Teknologi Malaysia Mohsin Mohd Sies, Universiti Teknologi Malaysia Jasman Zainal, Universiti Teknologi Malaysia Muhammad Arif Sazali, Universiti Teknologi Malaysia Muhammad Syahir Sarkawi, Universiti Teknologi Malaysia Nur Syazwani Mohd Ali, Universiti Teknologi Malaysia Khairulnadzmi Jamaluddin, Universiti Teknologi Malaysia Abdul Aziz Mohamed, Malaysian Nuclear Society Faridah Mohamad Idris, Malaysian Nuclear Agency Julie Andrianny Murshidi, Malaysian Nuclear Agency Faizal K P Kunchi Mohamed, Universiti Kebangsaan Malaysia Hassan Mohamed, Universiti Tenaga Nasional Abu Hassan Husin, Universiti Teknologi MARA All papers have been peer-reviewed List of Supporting/Sponsoring Organisations, Preface, Contents, iNuSTEC2021 Organising Committee, Inustec 2021 Awards And Recognition, Acknowledgement and Images are available in this pdf

10,378 citations2 viewsFull text
DOI: 10.1088/1757-899x/1231/1/011001
2022 · BMC Nursing

Development and evaluation of an electronic nursing documentation system

Mohsen Shafiee, Mostafa Shanbehzadeh, Zeinab Nassari, Hadi Kazemi-Arpanahi

BACKGROUND: Nursing documentation is a critical aspect of the nursing care workflow. There is a varying degree in how detailed nursing reports are described in scientific literature and care practice, and no uniform structured documentation is provided. This study aimed to describe the process of designing and evaluating the content of an electronic clinical nursing documentation system (ECNDS) to provide consistent and unified reporting in this context. METHODS: A four-step sequential methodological approach was utilized. The Minimum Data Set (MDS) development process consisted of two phases, as follows: First, a literature review was performed to attain an exhaustive overview of the relevant elements of nursing and map the available evidence underpinning the development of the MDS. Then, the data included from the literature review were analyzed using a two-round Delphi study with content validation by an expert panel. Afterward, the ECNDS was developed according to the finalized MDS, and eventually, its performance was evaluated by involving the end-users. RESULTS: The proposed MDS was divided into administrative and clinical sections; including nursing assessment and the nursing diagnosis process. Then, a web-based system with modular and layered architecture was developed based on the derived MDS. Finally, to evaluate the developed system, a survey of 150 registered nurses (RNs) was conducted to identify the positive and negative impacts of the system. CONCLUSIONS: The developed system is suitable for the documentation of patient care in nursing care plans within a legal, ethical, and professional framework. However, nurses need further training in documenting patient care according to the nursing process, and in using the standard reporting templates to increase patient safety and improve documentation.

38 citations0 viewsFull text
DOI: 10.1186/s12912-021-00790-1
2022 · Open Journal of Social Sciences

Developing Preservice Teachers’ Scientific Problem-Solving Skills Using a Pragmatic Approach to Physics: The Case of Gbewaa College of Education

Anthony Baawuo, Emmanuel Issah Azuuga, Edward Apenen Adakudugu, Issaka Abdulai

This research aimed at developing preservice-teachers’ scientific problem-solving skills after taking part in active learning in an introductory science lesson in semester two of the 2020/2021 academic year. The researchers engaged 150 level hundred preservice-teachers for five (5) weeks. Pre-test and post-test designs were employed to collect data for both quantitative and qualitative analyses. Ten active learning practices were performed throughout the semester. The problem-solving assessment used was T-TEL and rubrics were used to develop the research instrument to evaluate preservice teachers’ problem-solving skills. A Sample group interview was conducted to obtain qualitative data on preservice teachers’ opinions of active learning activities. A sample t-test was used to compare problem-solving pre-test and post-test scores in the class. The data collected and content analysis was used to summarize preservice teachers’ opinions. The results revealed their problem-solving skills were highly improved after taking part in active learning processes at 0.05 confident levels. Preservice teachers expressed their opinions positively toward active learning processes and showed a willingness to participate actively in the next lesson using the same learning approach.

1 citations0 viewsFull text
DOI: 10.4236/jss.2022.109020
2022 · arXiv (Cornell University)

Event Generators for High-Energy Physics Experiments

J. M. Campbell, M. Diefenthaler, T. J. Hobbs, Stefan Höche, Joshua Isaacson, Felix Kling, S. Mrenna, J. Reuter, S. Alioli, J…

We provide an overview of the status of Monte-Carlo event generators for high-energy particle physics. Guided by the experimental needs and requirements, we highlight areas of active development, and opportunities for future improvements. Particular emphasis is given to physics models and algorithms that are employed across a variety of experiments. These common themes in event generator development lead to a more comprehensive understanding of physics at the highest energies and intensities, and allow models to be tested against a wealth of data that have been accumulated over the past decades. A cohesive approach to event generator development will allow these models to be further improved and systematic uncertainties to be reduced, directly contributing to future experimental success. Event generators are part of a much larger ecosystem of computational tools. They typically involve a number of unknown model parameters that must be tuned to experimental data, while maintaining the integrity of the underlying physics models. Making both these data, and the analyses with which they have been obtained accessible to future users is an essential aspect of open science and data preservation. It ensures the consistency of physics models across a variety of experiments.

57 citations1 viewsFull text
DOI: 10.3204/pubdb-2022-01425
2021 · Bulletin of the World Health Organization

National surgical, obstetric, anaesthesia and nursing plan, Nigeria

Justina O. Seyi‐Olajide, Jamie E. Anderson, Omolara Williams, Omolara Faboya, Joseph O. Amedu, Stanley Anyanwu, Abraham Beth…

Recent evidence suggests that strengthening surgical care within existing health systems will strengthen the overall health-care system. However, Nigeria's national strategic health development plan 2018-2022 placed little emphasis on surgical care. To address the gap, we worked with professional societies and other partners to develop the national surgical, obstetric, anaesthesia and nursing plan 2019-2023. The aim was to foster actions to prioritize surgical care for the achievement of universal health coverage. In addition to creating a costed strategy to strengthen surgical care, the plan included children's surgery and nursing: two key aspects that have been neglected in other national surgical plans. Pilot implementation of the plan began in 2020, supported by a nongovernmental organization with experience in surgical care in the region. We have created specific entry points to facilitate the pilot implementation. In the pilot, an electronic surgery registry has been created; personnel are being trained in life support; nurses are being trained in safe perioperative care; biomedical technicians and sterile supplies nurses are being trained in surgical instrument repair and maintenance; and research capacity is being strengthened. In addition, the mainstream media are being mobilized to improve awareness about the plan among policy-makers and the general population. Another development partner is interested in providing support for paediatric surgery, and a children's hospital is being planned. As funding is a key challenge to full implementation, we need innovative domestic funding strategies to support and sustain implementation.

50 citations0 viewsFull text
DOI: 10.2471/blt.20.280297
2021 · International Journal of Interactive Mobile Techn…

Promoting Interactive Teaching with ICT: Features of Intervention for the Realities in the Ghanaian Physics Senior High School Classroom

Elizabeth Darko Agyei, Douglas Darko Agyei

<p>This research reports on the design aspect of a bigger project which sought to design and implement information and communication technology (ICT)-based interventions for the purpose of developing pre-service teachers’ ICT competency for teaching physics in an interactive manner using a three-stage (design stage, implementation and evaluation stage, and documentation and reflection stage) design-based research approach. Using literature as a lens, this research examines the interventions that we designed in the first stage of the project with the intent to determine its features that promote interactive teaching and fit the Ghanaian senior high school physics classroom context. Findings show that the intervention with inherent features comprising of: a readily available, sustainable, context- and content-specific ICT teaching and learning environment; an ICT-oriented knowledge base for teachers’ uptake of ICT; an underlining framework for defining interactive and learner-centred teaching approach with ICT; ICT-driven interactive lesson objectives; an inquiry-driven, activity- and ICT-based learning material; and a collaborative classroom arrangement is appropriate and sensitive to the needs of the Ghanaian physics classroom context and, hence, possess the potential for promoting interactive teaching. The features of the interventions, as situated in the specific context of the research and implications of the findings are discussed.<strong></strong></p><p><strong> </strong></p>

16 citations2 viewsFull text
DOI: 10.3991/ijim.v15i19.22735
2021 · European Journal of Interactive Multimedia and Ed…

Enhancing Students’ Learning of Physics Concepts with Simulation as an Instructional ICT Tool

Elizabeth Darko Agyei, Douglas Darko Agyei

The dwindling interest and perceived difficulty experienced by science students in learning physics at the senior high school level of education in Ghana speak to the need for the creation of authentic instructional platforms that promote enhanced learning as well as motivate students’ interest in physics. This study used an explanatory case study design to examine the affordances of Physics Education Technology simulations (PhETs) as an instructional tool with the intent to explain how enhanced students’ learning of physics concepts with simulations through implementation processes are possible in the context of Ghana. Nine pre-service physics teachers were engaged as learners to mimic the role of senior high school science students in witnessing simulation-based physics lessons. Questionnaires, pre- and post-tests and focus group interviews were the data sources employed in this study. The results showed that the learners’ learning enhanced with the use of PhETs because their learning outcomes improved and also, they had positive experiences with the simulations. Consequently, the study advocates that enhanced learning of concepts in physics with simulations are possible through interactive implementation processes that are exploratory and demonstrative in nature and context-sensitive.

15 citations1 viewsFull text
DOI: 10.30935/ejimed/11259
2021 · EAST AFRICAN JOURNAL OF EDUCATION AND SOCIAL SCIE…

Effect of Practical Work on Physics Learning Effectiveness: A Case of a Senior High School in Ghana

Victor Antwi, Nelly Adjoa Sakyi-Hagan, Fortune Addo-Wuver, Bismark Asare

This study investigated the effect of practical work on students’ academic achievement, acquisition of scientific process, skills and attitudes towards the study of selected topics in electricity. Fifty (50) Form Two Physics students from a Senior High Technical School in the Kwaebibirem Municipal of the Eastern Region of Ghana participated in the study. Instruments used to collect data included a student learning evaluation form, questionnaire and pre-and-post-intervention tests. Data was analysed using descriptive statistics and Microsoft Excel 2010 Computer Software. The findings indicated that the students’ academic performance were enhanced, they acquired important scientific process skills needed for science practical work and developed positive attitudes towards science practical work. The study recommended that Physics teachers should adopt practical work as a teaching technique and as well be encouraged to teach concepts alongside with practical activities.

9 citations0 viewsFull text
DOI: 10.46606/eajess2021v02i03.0102
2021 · Computer Physics Communications

LAMMPS - a flexible simulation tool for particle-based materials modeling at the atomic, meso, and continuum scales

Aidan P. Thompson, Hasan Metin Aktulga, Richard A. Berger, Dan Bolintineanu, William M. Brown, Paul Crozier, Pieter J. in ’t…

Since the classical molecular dynamics simulator LAMMPS was released as an open source code in 2004, it has become a widely-used tool for particle-based modeling of materials at length scales ranging from atomic to mesoscale to continuum. Reasons for its popularity are that it provides a wide variety of particle interaction models for different materials, that it runs on any platform from a single CPU core to the largest supercomputers with accelerators, and that it gives users control over simulation details, either via the input script or by adding code for new interatomic potentials, constraints, diagnostics, or other features needed for their models. As a result, hundreds of people have contributed new capabilities to LAMMPS and it has grown from fifty thousand lines of code in 2004 to a million lines today. In this paper several of the fundamental algorithms used in LAMMPS are described along with the design strategies which have made it flexible for both users and developers. We also highlight some capabilities recently added to the code which were enabled by this flexibility, including dynamic load balancing, on-the-fly visualization, magnetic spin dynamics models, and quantum-accuracy machine learning interatomic potentials. Program Title: Large-scale Atomic/Molecular Massively Parallel Simulator (LAMMPS) CPC Library link to program files: https://doi.org/10.17632/cxbxs9btsv.1 Developer's repository link: https://github.com/lammps/lammps Licensing provisions: GPLv2 Programming language: C++, Python, C, Fortran Supplementary material: https://www.lammps.org Nature of problem: Many science applications in physics, chemistry, materials science, and related fields require parallel, scalable, and efficient generation of long, stable classical particle dynamics trajectories. Within this common problem definition, there lies a great diversity of use cases, distinguished by different particle interaction models, external constraints, as well as timescales and lengthscales ranging from atomic to mesoscale to macroscopic. Solution method: The LAMMPS code uses parallel spatial decomposition, distributed neighbor lists, and parallel FFTs for long-range Coulombic interactions [1]. The time integration algorithm is based on the Størmer-Verlet symplectic integrator [2], which provides better stability than higher-order non-symplectic methods. In addition, LAMMPS supports a wide range of interatomic potentials, constraints, diagnostics, software interfaces, and pre- and post-processing features. Additional comments including restrictions and unusual features: This paper serves as the definitive reference for the LAMMPS code. S. Plimpton, Fast parallel algorithms for short-range molecular dynamics. J. Comp. Phys. 117 (1995) 1–19. L. Verlet, Computer experiments on classical fluids: I. Thermodynamical properties of Lennard–Jones molecules, Phys. Rev. 159 (1967) 98–103.

12,124 citations1 viewsFull text
DOI: 10.1016/j.cpc.2021.108171
2021 · Biological reviews/Biological reviews of the Camb…

The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole‐rat biology

Rochelle Buffenstein, Vincent Amoroso, Blazej Andziak, Stanislav Avdieiev, Jorge Azpurua, Alison J. Barker, Nigel C. Bennett…

The naked mole-rat (Heterocephalus glaber) has fascinated zoologists for at least half a century. It has also generated considerable biomedical interest not only because of its extraordinary longevity, but also because of unusual protective features (e.g. its tolerance of variable oxygen availability), which may be pertinent to several human disease states, including ischemia/reperfusion injury and neurodegeneration. A recent article entitled 'Surprisingly long survival of premature conclusions about naked mole-rat biology' described 28 'myths' which, those authors claimed, are a 'perpetuation of beautiful, but falsified, hypotheses' and impede our understanding of this enigmatic mammal. Here, we re-examine each of these 'myths' based on evidence published in the scientific literature. Following Braude et al., we argue that these 'myths' fall into four main categories: (i) 'myths' that would be better described as oversimplifications, some of which persist solely in the popular press; (ii) 'myths' that are based on incomplete understanding, where more evidence is clearly needed; (iii) 'myths' where the accumulation of evidence over the years has led to a revision in interpretation, but where there is no significant disagreement among scientists currently working in the field; (iv) 'myths' where there is a genuine difference in opinion among active researchers, based on alternative interpretations of the available evidence. The term 'myth' is particularly inappropriate when applied to competing, evidence-based hypotheses, which form part of the normal evolution of scientific knowledge. Here, we provide a comprehensive critical review of naked mole-rat biology and attempt to clarify some of these misconceptions.

131 citations1 viewsFull text
DOI: 10.1111/brv.12791
2021 · Biological reviews/Biological reviews of the Camb…

The integrative biology of genetic dominance

Sylvain Billiard, Vincent Castric, Violaine Llaurens

Dominance is a basic property of inheritance systems describing the link between a diploid genotype at a single locus and the resulting phenotype. Models for the evolution of dominance have long been framed as an opposition between the irreconcilable views of Fisher in 1928 supporting the role of largely elusive dominance modifiers and Wright in 1929, who viewed dominance as an emerging property of the structure of enzymatic pathways. Recent theoretical and empirical advances however suggest that these opposing views can be reconciled, notably using models investigating the regulation of gene expression and developmental processes. In this more comprehensive framework, phenotypic dominance emerges from departures from linearity between any levels of integration in the genotype-to-phenotype map. Here, we review how these different models illuminate the emergence and evolution of dominance. We then detail recent empirical studies shedding new light on the diversity of molecular and physiological mechanisms underlying dominance and its evolution. By reconciling population genetics and functional biology, we hope our review will facilitate cross-talk among research fields in the integrative study of dominance evolution.

70 citations2 viewsFull text
DOI: 10.1111/brv.12786
2021 · Journal of Education and Training Studies

Junior High School Teachers’ Attitudes Toward Inquiry-Based Science Teaching: Enabling or Disabling Dispositions?

Salifu Maigari Mohammed, Kwaku Darko Amponsah

This study sought to examine whether junior high school teachers’ attitudes are enabling or disabling dispositions toward inquiry-based science teaching. We used concurrent triangulation mixed methods design involving surveys and multiple case studies to collect quantitative and qualitative data. We sampled 308 integrated science teachers and a subsample of 18 teachers from junior high schools in urban and rural areas. Validity and reliability of the questionnaire were satisfactory for research. Credibility and dependability of the semi-structured interview schedule were also sufficient. Findings suggest that most junior high school teachers in the study context hold weak unfavourable attitudes that are disabling dispositions toward inquiry-based science teaching. Findings also suggest that the combination of societal subjective norms, perceived context dependency, and weak unfavourable attitudes of most junior high school teachers adversely influence their intentions and behaviours toward inquiry-based science teaching. Findings further suggest that most teachers in the study context developed weak unfavourable attitudes partly because they never had inquiry-based science teaching and learning experiences when they were students. Again, the teachers developed weak general attitudes toward science teaching partly because most science teaching and learning experiences they had were in specific subjects such as biology, chemistry, and physics instead of general (integrated) science. We recommend frequent attitude-focused inquiry-based science in-service trainings for junior high school teachers. We also recommend reforms in education that engages preservice teachers in attitude-focused inquiry-based science teaching and learning experiences.

11 citations1 viewsFull text
DOI: 10.11114/jets.v9i7.5266
2021 · Nature Communications

The Welwitschia genome reveals a unique biology underpinning extreme longevity in deserts

Tao Wan, Zhiming Liu, Ilia J. Leitch, H. P. Xin, Gillian Maggs‐Kölling, Yanbing Gong, Zhen Li, Eugène Marais, Yiying Liao, C…

The gymnosperm Welwitschia mirabilis belongs to the ancient, enigmatic gnetophyte lineage. It is a unique desert plant with extreme longevity and two ever-elongating leaves. We present a chromosome-level assembly of its genome (6.8 Gb/1 C) together with methylome and transcriptome data to explore its astonishing biology. We also present a refined, high-quality assembly of Gnetum montanum to enhance our understanding of gnetophyte genome evolution. The Welwitschia genome has been shaped by a lineage-specific ancient, whole genome duplication (~86 million years ago) and more recently (1-2 million years) by bursts of retrotransposon activity. High levels of cytosine methylation (particularly at CHH motifs) are associated with retrotransposons, whilst long-term deamination has resulted in an exceptionally GC-poor genome. Changes in copy number and/or expression of gene families and transcription factors (e.g. R2R3MYB, SAUR) controlling cell growth, differentiation and metabolism underpin the plant's longevity and tolerance to temperature, nutrient and water stress.

99 citations4 viewsFull text
DOI: 10.1038/s41467-021-24528-4
2021 · Biomolecules

Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology

Mamona Nazir, Muhammad Saleem, Muhammad Imran Tousif, Muhammad Aijaz Anwar, Frank Surup, Iftikhar Ali, Daijie Wang, Nilufar …

Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.

114 citations2 viewsFull text
DOI: 10.3390/biom11070957
2021 · Agronomy

Biology, Diversity, Detection and Management of Fusarium oxysporum f. sp. niveum Causing Vascular Wilt Disease of Watermelon (Citrullus lanatus): A Review

Muhammad Ziaur Rahman, Khairulmazmi Ahmad, Abdulaziz Bashir Kutawa, Yasmeen Siddiqui, Norsazilawati Saad, Tan Geok Hun, Erne…

Fusarium oxysporum f. sp. niveum (Fon) is the causative agent of Fusarium wilt disease of watermelon; it is the most serious soil-borne pathogen around the globe. The yield loss is around 30–80% or even more, and is presently a major hindrance to watermelon cultivation worldwide. Initially, the infected watermelon plant shows symptoms like loss of turgor pressure of the leaves and vines that can be recovered at night. The progress of the disease in contaminated transplants turns into dull green to yellow and finally necrotic. When the fungus continues to colonize the xylem vessel, it usually forms more tyloses, finally limiting water movement and causing wilt. The correct identification of the pathogen is necessary for proper disease control. As such, the selection of a molecular marker could serve as an effective means of screening the pathogen. Additionally, different methods have also been reported for the identification of Fon. Therefore, this review focused on the comprehensive description of the biology, diversity, detection, aggressiveness, mycotoxin production, and eco-friendly management strategies of the Fusarium wilt disease of watermelon.

46 citations2 viewsFull text
DOI: 10.3390/agronomy11071310
2021 · Journal of Education and Learning Technology

Attitude of Students Towards the Study of Physics: A Case of Tamale College of Education, Ghana.

Moses Kojo Asare Mabee, Tahiru Zingani Haruna, Abdallah Salifu

The study examined the attitude of third-year science and mathematics students towards the study of Physics in the Tamale College of Education, Ghana. A case study involving a sample of one hundred and thirty–three students was adopted for the study. Using a structured questionnaire, data was collected from the selected sample. The Likert rating scale was adopted to indicate the extent of agreement or disagreement. General findings from the study indicated that the majority of the respondents had a negative perception towards the study of Physics. The research recommended that preferably only students who offered Elective Physics at the Senior High School level should be admitted to study Physics at the College level as this would facilitate the smooth teaching and learning of the subject. It was also suggested that Physics tutors should use innovative strategies to make the teaching and learning of the subject interesting and attractive. Keywords: Physics, attitude, students, tutor, positive, negative.

1 citations2 viewsFull text
DOI: 10.38159/jelt.2021212
2021 · Nature Reviews Physics

Physics-informed machine learning

George Em Karniadakis, Ioannis G. Kevrekidis, Lu Lu, Paris Perdikaris, Sifan Wang, Liu Yang

7,331 citations3 viewsFull text
DOI: 10.1038/s42254-021-00314-5
2021 · Nature Genetics

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology

Niamh Mullins, Andreas J. Forstner, Kevin S. O’Connell, Brandon J. Coombes, Jonathan R. I. Coleman, Zhen Qiao, Thomas D. Als…

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics. Integrating expression quantitative trait locus data implicated 15 genes robustly linked to bipolar disorder via gene expression, encoding druggable targets such as HTR6, MCHR1, DCLK3 and FURIN. Analyses of bipolar disorder subtypes indicated high but imperfect genetic correlation between bipolar disorder type I and II and identified additional associated loci. Together, these results advance our understanding of the biological etiology of bipolar disorder, identify novel therapeutic leads and prioritize genes for functional follow-up studies. Genome-wide association analyses of 41,917 bipolar disorder cases and 371,549 controls of European ancestry provide new insights into the etiology of this disorder and identify novel therapeutic leads and potential opportunities for drug repurposing.

1,622 citations2 viewsFull text
DOI: 10.1038/s41588-021-00857-4
2021 · ODU Digital Commons (Old Dominion University)

End-to-End Physics Event Generator

Yasir Alanazi

We apply generative adversarial network (GAN) technology to build an event generator that simulates particle production in electron-proton scattering that is free of theoretical assumptions about underlying particle dynamics. The difficulty of efficiently training a GAN event simulator lies in learning the complicated pat- terns of the distributions of the particles physical properties. We develop a GAN that selects a set of transformed features from particle momenta that can be generated easily by the generator, and uses these to produce a set of augmented features that improve the sensitivity of the discriminator. The new Feature-Augmented and Transformed GAN (FAT-GAN) is able to faithfully reproduce the distribution of final state electron momenta in inclusive electron scattering, without the need for input derived from domain-based theoretical assumptions. The developed technology can play a significant role in boosting the science of the Jefferson Lab 12 GeV program and the future Electron-Ion Collider.

0 citations1 viewsFull text
DOI: 10.25883/rjm3-mh93
2021 · The Journal of Open Source Software

performance: An R Package for Assessment, Comparison and Testing of Statistical Models

Daniel Lüdecke, Mattan S. Ben‐Shachar, Indrajeet Patil, Philip Waggoner, Dominique Makowski

A crucial part of statistical analysis is evaluating a model's quality and fit, or performance. During analysis, especially with regression models, investigating the fit of models to data also often involves selecting the best fitting model amongst many competing models. Upon investigation, fit indices should also be reported both visually and numerically to bring readers in on the investigative effort.

5,589 citations0 viewsFull text
DOI: 10.21105/joss.03139
2021 · BMC Nursing

Professional image of nursing and midwifery in East Africa: an exploratory analysis

Eunice Ndirangu‐Mugo, Ahmed M. Sarki, Columba Mbekenga, Grace Edwards

BACKGROUND: Evidence suggests that there is a negative image of nursing and midwifery that does not promote these professions as attractive career options. Furthermore, there is a paucity of studies documenting how nursing and midwifery is perceived in East Africa and where such studies exist they are country-specific. The aim of this study was to explore views regarding the image of nursing and midwifery among nurses and midwives in three East African countries, Kenya, Tanzania and Uganda. METHODS: An exploratory descriptive cross-sectional study administered online using Survey Monkey Questionnaires assessed the views and perceptions of nurses and midwives regarding the image of nursing and midwifery professions. Descriptive statistics and Pearson's Chi square tests were used to analyse the data. The semi-structured questions were analysed using content analysis. RESULTS: A total of 551 participants took part in the study. The majority were females (61.8%), registered nurses/midwives (45.8%), and aged 30-39 years (34.2%). Most of the respondents were from Kenya (39.7%) and Uganda (32.9%). About two-thirds of the nurses and midwives in this study perceived nursing/midwifery as both trusted and respected professions and expressed having a level of control over how their image was portrayed. Conversely, the nurses and midwives were conscious that the public had mixed responses about the nursing/midwifery professions specifically, some members of the public described nurses/midwives as professionals, knowledgeable and caring, others perceived nurses/midwives to be rude, cruel, unkind, lazy, unkempt, and maids. CONCLUSION: This study offers an interesting insight about the image of nursing/midwifery in East Africa. Findings from this study will inform policy makers and educators about key concepts that affect the image of nursing and midwifery in East Africa. The findings will be used to design marketing materials to help improve the image of nursing and midwifery in the region and other African countries.

37 citations0 viewsFull text
DOI: 10.1186/s12912-020-00531-w