Research papers
2009 · Bioinformatics · 6,696 citations
Abstract Summary: The Biopython project is a mature open source international collaboration of volunteer developers, providing Python libraries for a wide range of bioinformatics problems. Biopython includes modules for reading and writing different sequence file formats and multiple sequence alignments, dealing with 3D macro molecular structures, interacting with common tools such as BLAST, ClustalW and EMBOSS, accessing key online databases, as well as providing numerical methods for statistical learning. Availability: Biopython is freely available, with documentation and source code at www.biopython.org under the Biopython license. Contact: All queries should be directed to the Biopython mailing lists, see www.biopython.org/wiki/_Mailing_listspeter.cock@scri.ac.uk.
2005 · Nature · 1,510 citations
2024 · Engineering Science & Technology Journal · 32 citations
This study provides a comprehensive review of the cutting-edge intersections of biology and engineering in the realm of medical therapeutics, focusing on the advancements and applications of synthetic biology. The main objectives were to explore the historical evolution, define the scope, and analyze the current state-of-the-art in synthetic biology, particularly in drug development and treatment strategies. The methodology employed a systematic literature review and content analysis, utilizing a range of academic databases to gather relevant peer-reviewed articles published between 2013 and 2023. Key findings revealED that synthetic biology, through the integration of engineering principles and biological systems, has led to significant innovations in medical therapeutics. These include the development of novel drug delivery systems, targeted therapies, and personalized medicine approaches. The study highlights the challenges and limitations in current synthetic biology approaches, such as ethical concerns, regulatory hurdles, and the need for interdisciplinary collaboration. The future landscape of synthetic biology in medicine is marked by both challenges and prospects. The field holds immense potential for addressing complex diseases and enhancing healthcare delivery, yet faces significant challenges in ethical considerations and regulatory frameworks. Strategic recommendations are provided for researchers, industry leaders, and policymakers, emphasizing the need for continuous innovation, ethical applications, and comprehensive regulatory strategies. Finally, synthetic biology stands as a transformative force in medical therapeutics, with the potential to revolutionize healthcare. Future research should focus on overcoming current limitations and exploring new applications, ensuring the field's continued advancement and contribution to global healthcare. Keywords: Synthetic Biology, Medical Therapeutics, Drug Development, Bioengineering.
2023 · Health and Technology · 6 citations
2005 · AIP conference proceedings · 2 citations
2025 · Journal of Applied Clinical Medical Physics · 1 citations
PURPOSE: To promote diversity in Science, Technology, Engineering, and Mathematics (STEM), an educational presentation and hands-on session was organised to raise awareness of STEM career opportunities among high school girls to introduce the students to the field of medical physics. MATERIALS AND METHODS: The study involved 65 first-year Senior High School girls, aged 13-16, pursuing general science in Accra, Ghana. This initiative, organised by the Girls Excellence Movement (GEM) in collaboration with a United States (US) institution, implemented the "heroes in radiation oncology" program, which included a relatable presentation and hands-on experience in simulation to treatment planning activities. The program's effectiveness was assessed through pre-and post-assessment surveys, and a thematic analysis of student feedback. RESULTS: Participants' awareness of career fields showed an interest in traditional healthcare professions (92%) and engineering (73.8%), with minimal medical physics awareness (12.3%). Post-presentation survey showed a significant change in participants' perception of medical physics 87.3%. Thematic analysis revealed increased awareness, understanding, and interest, dispelled misconceptions about radiation safety, and highlighted the interdisciplinary nature and career opportunities. The presentation was successful in inspiring participants and expanding their perspectives on medical physics. CONCLUSION: The program raised awareness of medical physics among participants, many of whom were previously unfamiliar with the field. Participants reported a newfound understanding of the interdisciplinary nature of medical physics, its connections to biology, mathematics, and engineering.This program can easily be reproduced in community and school outreaches.
2026 · Physica Medica